Guiding ATM to broken DNA

被引:46
作者
Abraham, RT [1 ]
Tibbetts, RS
机构
[1] Burnham Inst, Signal Transduct Program, La Jolla, CA 92037 USA
[2] Univ Wisconsin, Dept Pharmacol, Madison, WI 53706 USA
关键词
D O I
10.1126/science.1112069
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:510 / 511
页数:2
相关论文
共 11 条
[1]   DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation [J].
Bakkenist, CJ ;
Kastan, MB .
NATURE, 2003, 421 (6922) :499-506
[2]   Initiating cellular stress responses [J].
Bakkenist, CJ ;
Kastan, MB .
CELL, 2004, 118 (01) :9-17
[3]   The Mre11 complex is required for ATM activation and the G2/M checkpoint [J].
Carson, CT ;
Schwartz, RA ;
Stracker, TH ;
Lilley, CE ;
Lee, DV ;
Weitzman, MD .
EMBO JOURNAL, 2003, 22 (24) :6610-6620
[4]   Mre11 assembles linear DNA fragments into DNA damage signaling complexes [J].
Costanzo, V ;
Paull, T ;
Gottesman, M ;
Gautier, J .
PLOS BIOLOGY, 2004, 2 (05) :600-609
[5]   The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling [J].
D'Amours, D ;
Jackson, SP .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (05) :317-327
[6]  
FATCK J, 2005, NATURE, V434, P605
[7]   Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex [J].
Lee, JH ;
Paull, TT .
SCIENCE, 2004, 304 (5667) :93-96
[8]   ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex [J].
Lee, JH ;
Paull, TT .
SCIENCE, 2005, 308 (5721) :551-554
[9]   The Mre11 complex and ATM: collaborating to navigate S phase [J].
Petrini, JHJ .
CURRENT OPINION IN CELL BIOLOGY, 2000, 12 (03) :293-296
[10]   ATM and related protein kinases: Safeguarding genome integrity [J].
Shiloh, Y .
NATURE REVIEWS CANCER, 2003, 3 (03) :155-168