Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy

被引：22

作者：

Anttila, Sami ^{[1
,2
]}

Huuhka, Kaija ^{[1
,2
]}

Huuhka, Martti ^{[1
,2
]}

Illi, Ari ^{[2
,3
]}

Rontu, Riikka ^{[2
]}

Leinonen, Esa ^{[1
,2
]}

Lehtimaki, Terho ^{[2
]}

机构：

[1] Tampere Univ Hosp, Dept Psychiat, Pitkaniemi 33380, Finland

[2] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland

[3] Kanta Hame Cent Hosp, Dept Psychiat, Hameenlinna, Finland

来源：

PHARMACOGENOMICS JOURNAL | 2008年 / 8卷 / 02期

关键词：

COMT; polymorphism; major depression; electroconvulsive therapy; ECT;

D O I：

10.1038/sj.tpj.6500468

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Several lines of evidence suggest that catechol-O-methyltransferase (COMT) may be associated with treatment response in depression. We conducted a study on 119 patients with treatment-refractory depression admitted consecutively for electroconvulsive therapy (ECT). The COMT high/high genotype leads to a higher enzyme activity and thus lowers dopaminergic activity in the prefrontal cortex. In the present sample, those homozygous to high-active allele of COMT responded significantly more frequently to ECT.

引用

页码：113 / 116

页数：4

共 18 条

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