Fibroblast adhesion on unidirectional polymeric nanofilms

被引：6

作者：

Christophis, Christof ^{[3
]}

Sekeroglu, Koray ^{[1
,2
]}

Demirel, Gokhan ^{[1
,2
]}

Thome, Isabel ^{[3
,4
]}

Grunze, Michael ^{[3
,4
]}

Demirel, Melik C. ^{[1
,2
]}

Rosenhahn, Axel ^{[3
,4
]}

机构：

[1] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA

[2] Penn State Univ, Dept Engn Sci, University Pk, PA 16802 USA

[3] Heidelberg Univ, D-69120 Heidelberg, Germany

[4] Karlsruhe Inst Technol, Inst Funct Interfaces, IFG, D-76021 Karlsruhe, Germany

来源：

BIOINTERPHASES | 2011年 / 6卷 / 04期

关键词：

CELL-ADHESION; QUANTIFICATION; STRENGTH; CULTURE; FILMS;

D O I：

10.1116/1.3646093

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Nanotextured polymeric surfaces with inclined rods reveal highly anisotropic properties concerning wetting and adhesion. In this work, we report on the interaction of fibroblast cells with these highly anisotropic materials. The authors quantified removal of adherent cells from such surfaces by a laminar flow. The critical shear force needed for cell removal from the surface depends on the inclination direction. Based on electron microscopy cross sections we deduce that interactions of cellular filopodia extending into the nanotextured surface are causing the direction depending removal. (C) 2011 American Vacuum Society. [DOI: 10.1116/1.3646093]

引用

页码：158 / 163

页数：6

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