共 35 条
Roles of Bifocal, Homer, and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes
被引:48
作者:

Babu, K
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England

Cai, Y
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England

Bahri, S
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England

Yang, XH
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England

Chia, W
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England
机构:
[1] Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England
[2] Inst Mol & Cell Biol, Singapore 117609, Singapore
关键词:
Bifocal;
Homer;
Oskar;
F-actin;
anchoring;
D O I:
10.1101/gad.282604
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Transport, translation, and anchoring of osk mRNA and proteins are essential for posterior patterning of Drosophila embryos. Here we show that Homer and Bifocal act redundantly to promote posterior anchoring of the osk gene products. Disruption of actin microfilaments, which causes delocalization of Bifocal but not Homer from the oocyte cortex, severely disrupts anchoring of osk gene products only when Homer (not Bifocal) is absent. Our data suggest that two processes, one requiring Bifocal and an intact F-actin cytoskeleton and a second requiring Homer but independent of intact F-actin, may act redundantly to mediate posterior anchoring of the osk gene products.
引用
收藏
页码:138 / 143
页数:6
相关论文
共 35 条
[1]
The Drosophila bifocal gene encodes a novel protein which colocalizes with actin and is necessary for photoreceptor morphogenesis
[J].
Bahri, SM
;
Yang, XH
;
Chia, W
.
MOLECULAR AND CELLULAR BIOLOGY,
1997, 17 (09)
:5521-5529

Bahri, SM
论文数: 0 引用数: 0
h-index: 0
机构:
NATL UNIV SINGAPORE,INST MOL & CELL BIOL,SINGAPORE 119260,SINGAPORE NATL UNIV SINGAPORE,INST MOL & CELL BIOL,SINGAPORE 119260,SINGAPORE

Yang, XH
论文数: 0 引用数: 0
h-index: 0
机构:
NATL UNIV SINGAPORE,INST MOL & CELL BIOL,SINGAPORE 119260,SINGAPORE NATL UNIV SINGAPORE,INST MOL & CELL BIOL,SINGAPORE 119260,SINGAPORE

Chia, W
论文数: 0 引用数: 0
h-index: 0
机构:
NATL UNIV SINGAPORE,INST MOL & CELL BIOL,SINGAPORE 119260,SINGAPORE NATL UNIV SINGAPORE,INST MOL & CELL BIOL,SINGAPORE 119260,SINGAPORE
[2]
THE ROLE OF LOCALIZATION OF BICOID RNA IN ORGANIZING THE ANTERIOR PATTERN OF THE DROSOPHILA EMBRYO
[J].
BERLETH, T
;
BURRI, M
;
THOMA, G
;
BOPP, D
;
RICHSTEIN, S
;
FRIGERIO, G
;
NOLL, M
;
NUSSLEINVOLHARD, C
.
EMBO JOURNAL,
1988, 7 (06)
:1749-1756

BERLETH, T
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND

论文数: 引用数:
h-index:
机构:

THOMA, G
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND

BOPP, D
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND

RICHSTEIN, S
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND

FRIGERIO, G
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND

NOLL, M
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND

NUSSLEINVOLHARD, C
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND UNIV BASEL, BIOCTR, DEPT CELL BIOL, CH-4056 BASEL, SWITZERLAND
[3]
Homer: A protein that selectively binds metabotropic glutamate receptors
[J].
Brakeman, PR
;
Lanahan, AA
;
OBrien, R
;
Roche, K
;
Barnes, CA
;
Huganir, RL
;
Worley, PF
.
NATURE,
1997, 386 (6622)
:284-288

Brakeman, PR
论文数: 0 引用数: 0
h-index: 0
机构: JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

Lanahan, AA
论文数: 0 引用数: 0
h-index: 0
机构: JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

OBrien, R
论文数: 0 引用数: 0
h-index: 0
机构: JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

Roche, K
论文数: 0 引用数: 0
h-index: 0
机构: JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

Barnes, CA
论文数: 0 引用数: 0
h-index: 0
机构: JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

Huganir, RL
论文数: 0 引用数: 0
h-index: 0
机构: JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

Worley, PF
论文数: 0 引用数: 0
h-index: 0
机构: JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205
[4]
A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein
[J].
Brendza, RP
;
Serbus, LR
;
Duffy, JB
;
Saxton, WM
.
SCIENCE,
2000, 289 (5487)
:2120-2122

Brendza, RP
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Biol, Bloomington, IN 47405 USA Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

Serbus, LR
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Biol, Bloomington, IN 47405 USA Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

Duffy, JB
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Biol, Bloomington, IN 47405 USA Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

Saxton, WM
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Dept Biol, Bloomington, IN 47405 USA Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
[5]
Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts
[J].
Broadus, J
;
Doe, CQ
.
CURRENT BIOLOGY,
1997, 7 (11)
:827-835

Broadus, J
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV ILLINOIS,HOWARD HUGHES MED INST,DEPT CELL & STRUCT BIOL,URBANA,IL 61801 UNIV ILLINOIS,HOWARD HUGHES MED INST,DEPT CELL & STRUCT BIOL,URBANA,IL 61801

Doe, CQ
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV ILLINOIS,HOWARD HUGHES MED INST,DEPT CELL & STRUCT BIOL,URBANA,IL 61801 UNIV ILLINOIS,HOWARD HUGHES MED INST,DEPT CELL & STRUCT BIOL,URBANA,IL 61801
[6]
Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior
[J].
Cha, BJ
;
Serbus, LR
;
Koppetsch, BS
;
Theurkauf, WE
.
NATURE CELL BIOLOGY,
2002, 4 (08)
:592-598

Cha, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

Serbus, LR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

Koppetsch, BS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

Theurkauf, WE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
[7]
TRANSIENT POSTERIOR LOCALIZATION OF A KINESIN FUSION PROTEIN REFLECTS ANTEROPOSTERIOR POLARITY OF THE DROSOPHILA OOCYTE
[J].
CLARK, I
;
GINIGER, E
;
RUOHOLABAKER, H
;
JAN, LY
;
JAN, YN
.
CURRENT BIOLOGY,
1994, 4 (04)
:289-300

CLARK, I
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

GINIGER, E
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

RUOHOLABAKER, H
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

JAN, LY
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

JAN, YN
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
[8]
Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity
[J].
Diagana, TT
;
Thomas, U
;
Prokopenko, SN
;
Xiao, B
;
Worley, PF
;
Thomas, JB
.
JOURNAL OF NEUROSCIENCE,
2002, 22 (02)
:428-436

Diagana, TT
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, San Diego, CA 92186 USA

Thomas, U
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, San Diego, CA 92186 USA

Prokopenko, SN
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, San Diego, CA 92186 USA

Xiao, B
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, San Diego, CA 92186 USA

Worley, PF
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, San Diego, CA 92186 USA

Thomas, JB
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Mol Neurobiol Lab, San Diego, CA 92186 USA
[9]
OSKAR ORGANIZES THE GERM PLASM AND DIRECTS LOCALIZATION OF THE POSTERIOR DETERMINANT NANOS
[J].
EPHRUSSI, A
;
DICKINSON, LK
;
LEHMANN, R
.
CELL,
1991, 66 (01)
:37-50

EPHRUSSI, A
论文数: 0 引用数: 0
h-index: 0
机构: MIT,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02142

DICKINSON, LK
论文数: 0 引用数: 0
h-index: 0
机构: MIT,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02142

LEHMANN, R
论文数: 0 引用数: 0
h-index: 0
机构: MIT,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02142
[10]
INDUCTION OF GERM-CELL FORMATION BY OSKAR
[J].
EPHRUSSI, A
;
LEHMANN, R
.
NATURE,
1992, 358 (6385)
:387-392

EPHRUSSI, A
论文数: 0 引用数: 0
h-index: 0
机构:
MIT,HOWARD HUGHES MED INST,WHITEHEAD INST BIOMED RES,DEPT BIOL,CAMBRIDGE,MA 02142 MIT,HOWARD HUGHES MED INST,WHITEHEAD INST BIOMED RES,DEPT BIOL,CAMBRIDGE,MA 02142

LEHMANN, R
论文数: 0 引用数: 0
h-index: 0
机构:
MIT,HOWARD HUGHES MED INST,WHITEHEAD INST BIOMED RES,DEPT BIOL,CAMBRIDGE,MA 02142 MIT,HOWARD HUGHES MED INST,WHITEHEAD INST BIOMED RES,DEPT BIOL,CAMBRIDGE,MA 02142