Roles of Bifocal, Homer, and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes

被引:48
作者
Babu, K
Cai, Y
Bahri, S
Yang, XH
Chia, W [1 ]
机构
[1] Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England
[2] Inst Mol & Cell Biol, Singapore 117609, Singapore
关键词
Bifocal; Homer; Oskar; F-actin; anchoring;
D O I
10.1101/gad.282604
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Transport, translation, and anchoring of osk mRNA and proteins are essential for posterior patterning of Drosophila embryos. Here we show that Homer and Bifocal act redundantly to promote posterior anchoring of the osk gene products. Disruption of actin microfilaments, which causes delocalization of Bifocal but not Homer from the oocyte cortex, severely disrupts anchoring of osk gene products only when Homer (not Bifocal) is absent. Our data suggest that two processes, one requiring Bifocal and an intact F-actin cytoskeleton and a second requiring Homer but independent of intact F-actin, may act redundantly to mediate posterior anchoring of the osk gene products.
引用
收藏
页码:138 / 143
页数:6
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