Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

被引：603

作者：

Sun, Chun-Yi ^{[1
]}

Qin, Chao ^{[1
]}

Wang, Xin-Long ^{[1
]}

Yang, Guang-Sheng ^{[1
]}

Shao, Kui-Zhan ^{[1
]}

Lan, Ya-Qian ^{[1
]}

Su, Zhong-Min ^{[1
]}

Huang, Peng ^{[1
]}

Wang, Chun-Gang ^{[1
]}

Wang, En-Bo ^{[1
]}

机构：

[1] NE Normal Univ, Inst Funct Mat Chem, Key Lab Polyoxometalate Sci, Minist Educ,Dept Chem, Changchun 130024, Peoples R China

来源：

DALTON TRANSACTIONS | 2012年 / 41卷 / 23期

关键词：

METAL-ORGANIC FRAMEWORKS; CRYSTAL-STRUCTURES; TUMOR ACIDITY; 5-FLUOROURACIL; ADSORPTION; GENERATION; SEPARATION; OXIDATION; VACCINES; POROSITY;

D O I：

10.1039/c2dt30357d

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.

引用

收藏

页码：6906 / 6909

页数：4

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