CNS GLP-1 regulation of peripheral glucose homeostasis

被引：63

作者：

Sandoval, Darleen ^{[1
]}

机构：

[1] Univ Cincinnati, Genome Res Inst, Dept Psychiat, Cincinnati, OH 45237 USA

来源：

PHYSIOLOGY & BEHAVIOR | 2008年 / 94卷 / 05期

关键词：

hypothalamus; glucose metabolism; GLP-1;

D O I：

10.1016/j.physbeh.2008.04.018

中图分类号：

B84 [心理学];

学科分类号：

04 [教育学]; 0402 [心理学];

摘要：

Current models hold that peripheral and CNS GLP-1 signaling operate as distinct systems whereby CNS GLP-1 regulates food intake and circulating GLP-1 regulates glucose homeostasis. There is accumulating evidence that the arcuate nucleus, an area of the CNS that regulates energy homeostasis, responds to hormones and nutrients to regulate glucose homeostasis as well. Recent data suggest that GLP-1 may be another signal acting on the arcuate to regulate glucose homeostasis challenging the conventional model of GLP-1 physiology. This review discusses the peripheral and central GLP-1 systems and presents a model whereby these systems are integrated in regulation of glucose homeostasis. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：670 / 674

页数：5

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