Palladium-catalyzed addition of R2NH to double bonds.: Synthesis of α-amino tetrahydrofuran and pyran rings

被引：32

作者：

Cheng, XH ^{[1
]}

Hii, KK ^{[1
]}

机构：

[1] Kings Coll London, Dept Chem, London WC2R 2LS, England

来源：

TETRAHEDRON | 2001年 / 57卷 / 25期

关键词：

C-N bond formation; homogeneous catalysis; palladium; amination;

D O I：

10.1016/S0040-4020(01)00446-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient addition of (RRNH)-R-1-N-2 to unsaturated heterocycles has been achieved using palladium catalysts. The methodology was applied to the synthesis of a number of alpha -amino, tetrahydrofurans and pyrans. Nature of amine, ring size and catalyst were found to affect the reaction. Mechanistic aspects of the reactions were explored by deuterium labelling experiments. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5445 / 5450

页数：6

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