Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba

被引：101

作者：

Chen, DF ^{[1
]}

Zhang, SX

Wang, HK

Zhang, SY

Sun, QZ

Cosentino, LM

Lee, KH

机构：

[1] Shanghai Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China

[2] Univ N Carolina, Div Med Chem & Nat Prod, Sch Pharm, Chapel Hill, NC 27599 USA

[3] Biotech Res Labs, Rockville, MD USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期

关键词：

D O I：

10.1021/np980291d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new triterpene lactones, lancilactones A (1), B (2), and C (3), together with the known kadsulactone A (4), were isolated from the stems and roots of Kadsura lancilimba. Their structures and stereochemistries were determined primarily from mass and NMR spectral data. Compound 3 inhibited HIV replication with an EC50 value of 1.4 mu g/mL and a therapeutic index of greater than 71.4.

引用

页码：94 / 97

页数：4

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