Osteoblastic cells: Differentiation and trans-differentiation

被引：80

作者：

Kassem, Moustapha ^{[1
]}

Abdallah, Basem M. ^{[1
]}

Saleed, Hamid ^{[1
]}

机构：

[1] Univ So Denmark, Mol Endocrinol Lab KMEB, Dept Endocrinol, Odense Univ Hosp & Med Biotechnol Ctr, DK-5000 Odense, Denmark

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2008年 / 473卷 / 02期

关键词：

osteoblast; hMSC; stem cells; differentiation; trans-differentiation;

D O I：

10.1016/j.abb.2008.03.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation. (C) 2008 Elsevier Inc. All rights reserved.

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页码：183 / 187

页数：5

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