Degradation patterns and surface wettability of electrospun fibrous mats

被引：165

作者：

Cui, Wenguo ^{[1
]}

Li, Xiaohong ^{[1
]}

Zhou, Shaobing ^{[1
]}

Weng, Jie ^{[1
]}

机构：

[1] SW Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China

来源：

POLYMER DEGRADATION AND STABILITY | 2008年 / 93卷 / 03期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

degradation pattern; surface wettability; electrospinning; surface morphology; surface erosion;

D O I：

10.1016/j.polymdegradstab.2007.12.002

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Degradation profiles and surface wettability are critical for optimal application of electrospun fibrous mats as drug carriers, tissue growth scaffolds and wound dressing materials. The effect of surface morphologies and chemical groups on surface wettability, and the resulting matrix degradation profiles were firstly assessed for electrospun poly(D,L-lactide) (PDLLA) and poly(D,L-lactide)-poly(ethylene glycol) (PELA) fibers. The air entrapment between the fiber interfaces clarified the effects of various surface morphologies on the surface wettability. Chemical groups with lower binding energy were enriched on the fiber surface due to the high voltage of the electrospinning process, and a surface erosion pattern was detected in the degradation of electrospun PDLLA fibers, which was quite different from the bulk degradation pattern for other forms of PDLLA. Contributed by the hydrophilic poly(ethylene glycol) segments, the degradation of electrospun PELA fibers with hydrophobic surface followed a pattern different from surface erosion and typical bulk degradation. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：731 / 738

页数：8

共 30 条

[1] Utilizing acid pretreatment and electrospinning to improve biocompatibility of poly(glycolic acid) for tissue engineering [J].