Synthesis and absolute stereochemistry of roseophilin

被引：112

作者：

Harrington, PE ^{[1
]}

Tius, MA ^{[1
]}

机构：

[1] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2001年 / 123卷 / 35期

关键词：

D O I：

10.1021/ja011242h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantiospecific total synthesis of natural roseophilin has been completed in 7.0% overall yield over 15 steps by means of an asymmetric cyclopentannelation. This establishes the absolute configuration of the natural product as 22R,23R. Cyclopentenone (+)-12 was prepared in 78% yield and 86% ee in the key step.

引用

页码：8509 / 8514

页数：6

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