Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41)

被引：29

作者：

Chen, Rui ^{[1
,2
]}

Moriya, Junji ^{[1
]}

Yamakawa, Jun-ichi ^{[1
]}

Takahashi, Takashi ^{[1
]}

Li, Qian ^{[1
,3
]}

Morimoto, Shigeto ^{[4
]}

Iwai, Kunimitsu ^{[4
]}

Sumino, Hiroyuki ^{[5
]}

Yamaguchi, Nobuo ^{[6
]}

Kanda, Tsugiyasu ^{[1
]}

机构：

[1] Kanazawa Med Univ, Dept Gen Med, Uchinada, Ishikawa 9200293, Japan

[2] Huazhong Univ Sci & Technol, Union Hosp, Dept Tradit Chinese Med, Wuhan 430074, Peoples R China

[3] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Wuhan 430074, Peoples R China

[4] Kanazawa Med Univ, Dept Geriatr Med, Uchinada, Ishikawa 9200293, Japan

[5] Gunma Univ, Grad Sch Med, Dept Med & Biol Sci, Gunma, Japan

[6] Kanazawa Med Univ, Dept Serol, Uchinada, Ishikawa 9200293, Japan

来源：

NEUROCHEMICAL RESEARCH | 2008年 / 33卷 / 09期

关键词：

brain atrophy; brain-derived neurotrophic factor; chronic fatigue syndrome; Hochu-ekki-to;

D O I：

10.1007/s11064-008-9620-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is associated with the main symptoms of chronic fatigue sydrome (CFS) and neuron apoptosis. Nevertheless, no study has been performed directly to explore the relationship between CFS, BDNF and neuron apoptosis. We induced a CFS model by six injections of killed Brucella abortus antigen in BALB/c mice and treated them with Hochu-ekki-to (TJ-41). Daily running activity, body weight (BW), ratio of cerebral weight to BW (CW/BW) and expression levels of BDNF and Bcl-2 mRNA in the hippocampus were determined. The daily activity and CW/BW decreased significantly in the CFS model. BDNF and Bcl-2 mRNA expression levels in the hippocampus were suppressed in the CFS model and TJ-41 treated mice, while no significant difference was found between them. We improved a murine model to investigate the relationship between CFS and brain dysfunction. In this model, reduced daily activity might have been associated with decreased hippocampal BDNF mRNA expression, hippocampal apoptosis and brain atrophy. TJ-41 increased the daily running activity of the model, which was independent of brain recovery.

引用

页码：1759 / 1767

页数：9

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