Effects of fluorine substitution of cytosine analogues on the binding affinity to HIV-1 reverse transcriptase

被引：4

作者：

Chong, YH ^{[1
]}

Choo, H ^{[1
]}

Chu, CK ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 02期

关键词：

fluorine; binding affinity; HIV-1 reverse trancscriptase; molecular dynamics;

D O I：

10.1016/j.bmcl.2003.10.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to find out the possible role of fluorine substituent in binding of the fluorinated cytidine analogues at the active site of HIV-1 RT, binding modes of several 5-fluoro cytidine analogues, such as FTC, D-dioxolane 5-FC and D-2'F-d4FC to the active site of HIV-1 reverse transcriptase, were compared by molecular dynamics studies. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：437 / 440

页数：4

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