Metastasis: a therapeutic target for cancer

被引：263

作者：

Steeg, Patricia S. ^{[1
]}

Theodorescu, Dan ^{[2
]}

机构：

[1] NCI, Womens Canc Sect, Mol Pharmacol Lab, Ctr Canc Res, Bethesda, MD 20892 USA

[2] Univ Virginia, Paul Mellon Urol Canc Inst, Charlottesville, VA 22908 USA

来源：

NATURE CLINICAL PRACTICE ONCOLOGY | 2008年 / 5卷 / 04期

关键词：

angiogenesis; bone; colonization; metastasis; tumorigenesis;

D O I：

10.1038/ncponc1066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis remains the major driver of mortality in patients with cancer. Our growing body of knowledge regarding this process provides the basis for the development of molecularly targeted therapeutics aimed at the tumor cell or its interaction with the host microenvironment. Here we discuss the similarity and differences between primary tumors and metastases, pathways controlling the colonization of a distant organ, and incorporation of antimetastatic therapies into clinical testing.

引用

页码：206 / 219

页数：14

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