Fabrication of a novel chitosan scaffold with asymmetric structure for guided tissue regeneration

被引：17

作者：

Yang, Ling ^{[1
,2
]}

Lu, Wentao ^{[1
,2
]}

Pang, Yichuan ^{[1
,2
]}

Huang, Xiaofei ^{[1
,2
]}

Wang, Zhengke ^{[1
,2
]}

Qin, An ^{[3
]}

Hu, Qiaoling ^{[1
,2
]}

机构：

[1] Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Dept Polymer Sci & Engn, Hangzhou 310027, Zhejiang, Peoples R China

[2] Key Lab Adsorpt & Separat Mat & Technol Zhejiang, Hangzhou 310027, Zhejiang, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthoped Implants, Dept Orthoped,Sch Med, Shanghai, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 75期

基金：

中国国家自然科学基金;

关键词：

PARTICLE-INDUCED OSTEOLYSIS; NF-KAPPA-B; BONE REGENERATION; PERIODONTAL TISSUE; MECHANICAL-PROPERTIES; MEMBRANE; COMPOSITE; DEFECTS; OSTEOCLASTOGENESIS; ORIENTATION;

D O I：

10.1039/c6ra12370h

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A novel chitosan (CS)-based asymmetric scaffold composed of a dense layer and a loose layer was fabricated via the self-deposition approach. The micro-structure and mechanical properties were verified to satisfy the criteria for the guided tissue regeneration (GTR) membrane. The in vitro biocompatibility of the scaffold was verified by the CCK-8 assays of MC3T3 osteoblastic cells. The rat skull defect model was applied to estimate the in vivo bone regeneration performance. The micro-CT and histological results manifested its outstanding bone regenerative ability and superior degradability over the Bio-gide (R) membrane. Considering the relative low expense and simple fabrication process, the prepared asymmetric CS scaffold is a prospective candidate for GTR therapy.

引用

页码：71567 / 71573

页数：7

共 45 条

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