Green tea: a new option for the prevention or control of osteoarthritis

被引：26

作者：

Katiyar, Santosh K. ^{[1
,2
]}

Raman, Chander ^{[3
]}

机构：

[1] Univ Alabama, Dept Dermatol, Birmingham, AL 35294 USA

[2] Birmingham VA Med Ctr, Birmingham, AL 35294 USA

[3] Univ Alabama, Div Clin Immunol & Rheumatol, Dept Med, Birmingham, AL 35294 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2011年 / 13卷 / 04期

关键词：

NITRIC-OXIDE SYNTHASE; HUMAN CHONDROCYTES; POLYPHENOLS; EXPRESSION; REPAIR; MICE;

D O I：

10.1186/ar3428

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

IL-1 beta is a major cytokine driving the inflammatory processes leading to the pathophysiology of osteoarthritis and other inflammatory diseases. Blockade of IL-1 beta activity using substances such as the naturally occurring IL-1 receptor antagonist or anti-IL-1 beta monoclonal antibody are currently being used or tested as therapy. However, such treatments are ineffective in osteoarthritis. In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1 beta-induced inflammatory cytokines, TNF alpha, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes. The use of green tea polyphenols may be beneficial as a therapeutic addition to biologics that control IL-1 beta activity by increasing effectiveness and/or reducing dosage.

引用

页数：2

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