The pharmacological profile of GABA receptors on cultured insect neurones

被引：18

作者：

Aydar, E ^{[1
]}

Beadle, DJ ^{[1
]}

机构：

[1] Oxford Brookes Univ, Sch Biol & Mol Sci, Oxford OX3 0BP, England

来源：

JOURNAL OF INSECT PHYSIOLOGY | 1999年 / 45卷 / 03期

关键词：

insect GABA receptors; GABA agonists; GABA antagonists; chloride channel blockers;

D O I：

10.1016/S0022-1910(98)00114-0

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Neuronal cultures of the cockroach, Periplaneta americana, were used to study the pharmacological profile of GABA receptors using the whole-cell-voltage clamp technique. The results indicated that insect GABA receptors are linked to a chloride channel that can be activated by both GABA(A) and GABA(C) receptor agonists. The receptors are blocked by GABA(A) chloride channel blockers and some insecticides but not by competitive GABA(A) receptor antagonists. The GABA(C) receptor competitive antagonists were either full or partial agonists of the cockroach GABA receptors. The receptors were modulated by the enantiomers of lindane. In conclusion, insect GABA receptors appear to have a distinct pharmacological profile that does not conform to either vertebrate GABA(A) or GABA(C) receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：213 / 219

页数：7

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