pH-Operated Mechanized Porous Silicon Nanoparticles

被引：133

作者：

Xue, Min ^{[1
]}

Zhong, Xing ^{[1
]}

Shaposhnik, Zory ^{[2
]}

Qu, Yongquan ^{[1
]}

Tamanoi, Fuyuhiko ^{[2
]}

Duan, Xiangfeng ^{[1
]}

Zink, Jeffrey I. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 23期

基金：

美国国家科学基金会;

关键词：

MULTISTAGE DELIVERY-SYSTEM; DRUG-DELIVERY; RELEASE; MICROPARTICLES; NANOVALVES;

D O I：

10.1021/ja201252e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Porous silicon nanoparticles (PSiNPs) were synthesized by silver-assisted electroless chemical etching of silicon nanowires generated on a silicon wafer. The rod-shaped particles (200-400 nm long and 100-200 nm in diameter) were derivatized with a cyclodextrin-based nano-valve that was closed at the physiological pH of 7.4 but open at pH <6. Release profiles in water and tissue culture media showed that no cargo leaked when the valves were closed and that release occurred immediately after acidification. In vitro studies using human pancreatic carcinoma PANC-1 cells proved that these PSiNPs were endocytosed and carried cargo molecules into the cells and released them in response to lysosomal acidity. These studies show that PSiNPs can serve as an autonomously functioning delivery platform in biological systems and open new possibilities for drug delivery.

引用

页码：8798 / 8801

页数：4

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