Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium

被引：131

作者：

Boffetta, Paolo ^{[1
,2
]}

McLerran, Dale ^{[3
]}

Chen, Yu ^{[4
]}

Inoue, Manami ^{[5
]}

Sinha, Rashmi ^{[6
]}

He, Jiang ^{[7
]}

Gupta, Prakash Chandra ^{[8
]}

Tsugane, Shoichiro ^{[5
]}

Irie, Fujiko ^{[9
]}

Tamakoshi, Akiko ^{[10
]}

Gao, Yu-Tang ^{[11
]}

Shu, Xiao-Ou ^{[12
]}

Wang, Renwei ^{[13
]}

Tsuji, Ichiro ^{[14
]}

Kuriyama, Shinichi ^{[14
]}

Matsuo, Keitaro ^{[15
]}

Satoh, Hiroshi

Chen, Chien-Jen ^{[16
,17
]}

Yuan, Jian-Min

Yoo, Keun-Young ^{[18
]}

Ahsan, Habibul ^{[19
,20
,21
]}

Pan, Wen-Harn ^{[17
,22
,23
]}

Gu, Dongfeng ^{[24
,25
,26
]}

Pednekar, Mangesh Suryakant ^{[8
]}

Sasazuki, Shizuka ^{[5
]}

Sairenchi, Toshimi ^{[27
]}

Yang, Gong ^{[12
]}

Xiang, Yong-Bing ^{[11
]}

Nagai, Masato ^{[14
]}

Tanaka, Hideo ^{[15
]}

Nishino, Yoshikazu ^{[28
]}

You, San-Lin ^{[16
]}

Koh, Woon-Puay ^{[29
]}

Park, Sue K. ^{[30
,31
,32
]}

Shen, Chen-Yang ^{[33
,34
]}

Thornquist, Mark ^{[3
]}

Kang, Daehee ^{[18
]}

Rolland, Betsy ^{[3
]}

Feng, Ziding ^{[3
]}

Zheng, Wei ^{[12
]}

Potter, John D. ^{[3
]}

机构：

[1] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA

[2] Int Prevent Res Inst, Lyon, France

[3] Fred Hutchinson Canc Res Ctr, Dept Publ Hlth Sci, Seattle, WA 98104 USA

[4] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[5] Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Epidemiol & Prevent Div, Tokyo 104, Japan

[6] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[7] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA

[8] Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India

[9] Ibaraki Prefectural Govt, Dept Hlth & Social Serv, Ibaraki, Japan

[10] Aichi Med Univ, Sch Med, Dept Publ Hlth, Aichi, Japan

[11] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

[12] Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Dept Med, Div Epidemiol, Nashville, TN USA

[13] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA

[14] Tohoku Univ, Grad Sch Med, Dept Publ Hlth & Forens Med, Div Epidemiol, Sendai, Miyagi 980, Japan

[15] Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi 464, Japan

[16] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

[17] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10764, Taiwan

[18] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[19] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA

[20] Univ Chicago, Dept Med & Human Genet, Chicago, IL 60637 USA

[21] Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA

[22] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

[23] Natl Taiwan Univ, Dept Biochem Sci & Technol, Taipei 10764, Taiwan

[24] Fuwai Hosp, Beijing, Peoples R China

[25] Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100730, Peoples R China

[26] Peking Union Med Coll, China Natl Ctr Cardiovasc Dis, Beijing 100021, Peoples R China

[27] Dokkyo Med Univ, Sch Med, Dept Publ Hlth, Mibu, Tochigi, Japan

[28] Miyagi Canc Ctr, Res Inst, Div Epidemiol, Sendai, Miyagi, Japan

[29] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Epidemiol & Publ Hlth, Singapore 117595, Singapore

[30] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[31] Seoul Natl Univ, Canc Res Inst, Seoul, South Korea

[32] Seoul Natl Univ, Inst Hlth Policy & Management, Seoul, South Korea

[33] Acad Sinica, Inst Biomed Sci, Taiwan Biobank, Taipei, Taiwan

[34] China Med Univ, Grad Inst Environm Sci, Taichung, Taiwan

来源：

PLOS ONE | 2011年 / 6卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

CARDIOVASCULAR RISK-FACTORS; INSULIN SENSITIVITY; GLUCOSE-TOLERANCE; ABDOMINAL OBESITY; FAT DISTRIBUTION; LIFE-STYLE; TYPE-2; PREVALENCE; MELLITUS; POPULATION;

D O I：

10.1371/journal.pone.0019930

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Background: The occurrence of diabetes has greatly increased in low- and middle-income countries, particularly in Asia, as has the prevalence of overweight and obesity; in European-derived populations, overweight and obesity are established causes of diabetes. The shape of the association of overweight and obesity with diabetes risk and its overall impact have not been adequately studied in Asia. Methods and Findings: A pooled cross-sectional analysis was conducted to evaluate the association between baseline body mass index (BMI, measured as weight in kg divided by the square of height in m) and self-reported diabetes status in over 900,000 individuals recruited in 18 cohorts from Bangladesh, China, India, Japan, Korea, Singapore and Taiwan. Logistic regression models were fitted to calculate cohort-specific odds ratios (OR) of diabetes for categories of increasing BMI, after adjustment for potential confounding factors. OR were pooled across cohorts using a random-effects meta-analysis. The sex- and age-adjusted prevalence of diabetes was 4.3% in the overall population, ranging from 0.5% to 8.2% across participating cohorts. Using the category 22.5-24.9 Kg/m(2) as reference, the OR for diabetes spanned from 0.58 (95% confidence interval [CI] 0.31, 0.76) for BMI lower than 15.0 kg/m(2) to 2.23 (95% CI 1.86, 2.67) for BMI higher than 34.9 kg/m(2). The positive association between BMI and diabetes prevalence was present in all cohorts and in all subgroups of the study population, although the association was stronger in individuals below age 50 at baseline (p-value of interaction <0.001), in cohorts from India and Bangladesh (p<0.001), in individuals with low education (p-value 0.02), and in smokers (p-value 0.03); no differences were observed by gender, urban residence, or alcohol drinking. Conclusions: This study estimated the shape and the strength of the association between BMI and prevalence of diabetes in Asian populations and identified patterns of the association by age, country, and other risk factors for diabetes.

引用

页数：10

共 50 条

[1]

RELATIONSHIPS OF GENERALIZED AND REGIONAL ADIPOSITY TO INSULIN SENSITIVITY IN MEN [J].

ABATE, N ;

GARG, A ;

PESHOCK, RM ;

STRAYGUNDERSEN, J ;

GRUNDY, SM .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (01) :88-98

[2]

Ethnicity and type 2 diabetes - Focus on Asian Indians [J].

Abate, N ;

Chandalia, M .

JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2001, 15 (06) :320-327

[3]

A risk score for predicting incident diabetes in the Thai population [J].

Aekplakorn, Wichai ;

Bunnag, Pongamorn ;

Woodward, Mark ;

Sritara, Piyamitr ;

Cheepudomwit, Sayan ;

Yamwong, Sukit ;

Yipintsoi, Tada ;

Rajatanavin, Rajata .

DIABETES CARE, 2006, 29 (08) :1872-1877

[4]

[Anonymous], 2008, SAS/STAT 9.2 user's guide

[5]

International day for the evaluation of abdominal obesity (IDEA) -: A study of waist circumference, cardiovascular disease, and diabetes mellitus in 168 000 primary care patients in 63 countries [J].

Balkau, Beverley ;

Deanfield, John E. ;

Despres, Jean-Pierre ;

Bassand, Jean-Pierre ;

Fox, Keith A. A. ;

Smith, Sidney C., Jr. ;

Barter, Philip ;

Tan, Chee-Eng ;

Van Gaal, Luc ;

Wittchen, Hans-Ulrich ;

Massien, Christine ;

Haffner, Steven M. .

CIRCULATION, 2007, 116 (17) :1942-1951

[6]

TYPE 2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS, HYPERTENSION AND HYPERLIPEMIA (SYNDROME-X) - RELATION TO REDUCED FETAL GROWTH [J].

BARKER, DJP ;

HALES, CN ;

FALL, CHD ;

OSMOND, C ;

PHIPPS, K ;

CLARK, PMS .

DIABETOLOGIA, 1993, 36 (01) :62-67

[7]

A comparison of statistical methods for meta-analysis [J].

Brockwell, SE ;

Gordon, IR .

STATISTICS IN MEDICINE, 2001, 20 (06) :825-840

[8]

Diabetes in Asia Epidemiology, Risk Factors, and Pathophysiology [J].

Chan, Juliana C. N. ;

Malik, Vasanti ;

Jia, Weiping ;

Kadowaki, Takashi ;

Yajnik, Chittaranjan S. ;

Yoon, Kun-Ho ;

Hu, Frank B. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (20) :2129-2140

[9]

METAANALYSIS IN CLINICAL-TRIALS [J].

DERSIMONIAN, R ;

LAIRD, N .

CONTROLLED CLINICAL TRIALS, 1986, 7 (03) :177-188

[10]

ROLE OF DEEP ABDOMINAL FAT IN THE ASSOCIATION BETWEEN REGIONAL ADIPOSE-TISSUE DISTRIBUTION AND GLUCOSE-TOLERANCE IN OBESE WOMEN [J].

DESPRES, JP ;

NADEAU, A ;

TREMBLAY, A ;

FERLAND, M ;

MOORJANI, S ;

LUPIEN, PJ ;

THERIAULT, G ;

PINAULT, S ;

BOUCHARD, C .

DIABETES, 1989, 38 (03) :304-309

← 1 2 3 4 5 →