Getting to the end: Telomerase access in yeast and humans

被引：96

作者：

Vega, LR ^{[1
]}

Mateyak, MK ^{[1
]}

Zakian, VA ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1256

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In organisms with linear chromosomes, telomeres are essential to maintain genome integrity. However, inappropriate telomere addition, for example to double-stranded DNA breaks, might stabilize deleterious genetic changes. Therefore, telomere addition by telomerase is highly regulated, for example by mechanisms that determine the accessibility of telomeres to elongation by telomerase. These mechanisms, which have been studied mainly in budding yeast and human cell culture, can be subdivided into two classes: mechanisms that modulate the telomeric chromatin structure and those that sequester active telomerase from chromosome ends.

引用

收藏

页码：948 / 959

页数：12

相关论文

共 159 条

[1]

Akiyama M, 2003, CANCER RES, V63, P18

[2] Rap1p telomere association is not required for mitotic stability of a C3TA2 telomere in yeast [J].

Alexander, MK ;

Zakian, VA .

EMBO JOURNAL, 2003, 22 (07) :1688-1696

[3] Targeting assay to study the cis functions of human telomeric proteins:: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2 [J].

Ancelin, K ;

Brunori, M ;

Bauwens, S ;

Koering, CE ;

Brun, C ;

Ricoul, M ;

Pommier, JP ;

Sabatier, L ;

Gilson, E .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (10) :3474-3487

[4] Putative telomere-recruiting domain in the catalytic subunit of human telomerase [J].

Armbruster, BN ;

Etheridge, KT ;

Broccoli, D ;

Counter, CM .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (09) :3237-3246

[5] N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo [J].

Armbruster, BN ;

Banik, SSR ;

Guo, CH ;

Smith, AC ;

Counter, CM .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (22) :7775-7786

[6] DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes [J].

Bailey, SM ;

Meyne, J ;

Chen, DJ ;

Kurimasa, A ;

Li, GC ;

Lehnert, BE ;

Goodwin, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :14899-14904

[7] Strand-specific postreplicative processing of mammalian telomeres [J].

Bailey, SM ;

Cornforth, MN ;

Kurimasa, A ;

Chen, DJ ;

Goodwin, EH .

SCIENCE, 2001, 293 (5539) :2462-2465

[8] Human Pot1 (Protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing [J].

Baumann, P ;

Podell, E ;

Cech, TR .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (22) :8079-8087

[9] Pot1, the putative telomere end-binding protein in fission yeast and humans [J].

Baumann, P ;

Cech, TR .

SCIENCE, 2001, 292 (5519) :1171-1175

[10] Telomere maintenance in fission yeast requires an Est1 ortholog [J].

Beernink, HTH ;

Miller, K ;

Deshpande, A ;

Bucher, P ;

Cooper, JP .

CURRENT BIOLOGY, 2003, 13 (07) :575-580

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