A longitudinal study of operant responding in rats irradiated when 2 months old

被引：43

作者：

Rabin, BM ^{[1
]}

Joseph, JA

Shukitt-Hale, B

机构：

[1] Univ Maryland Baltimore Cty, Dept Psychol, Baltimore, MD 21250 USA

[2] Tufts Univ, USDA ARS, Human Nutr Res Ctr Aging, Boston, MA 02111 USA

来源：

RADIATION RESEARCH | 2005年 / 164卷 / 04期

关键词：

D O I：

10.1667/RR3349.1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two-month-old rats were exposed to Fe-56 particles (1, 1.5, 2 Gy; 1 GeV/nucleon). They were tested on the performance of an ascending fixed-ratio operant task (bar pressing for food reward) at 7, 11 and 15 months after irradiation. Previous research had shown that for the same rats tested at 3 months after exposure, only the rats exposed to 2 Gy of Fe-56 particles showed a significant disruption of performance compared to control (0 Gy) rats. When these rats were tested 7, 11 and 15 months after exposure, all irradiated groups showed significantly poorer performance than the controls. These results suggest that there is an interaction between irradiation and age such that Fe-56-particle-induced performance deficits can develop several months after exposure. (c) 2005 by Radiation Research Society.

引用

页码：552 / 555

页数：4

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