Aerobic ruthenium-catalyzed oxidative cyanation of tertiary amines with sodium cyanide

被引：448

作者：

Murahashi, SI

Komiya, N

Terai, H

Nakae, T

机构：

[1] Osaka Univ, Dept Chem, Grad Sch Engn Sci, Toyonaka, Osaka 5608531, Japan

[2] Okayama Univ Sci, Fac Engn, Dept Appl Chem, Okayama 7000005, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 50期

关键词：

D O I：

10.1021/ja0390303

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

RuCl3-catalyzed oxidative cyanation of tertiary amines with sodium cyanide under molecular oxygen (1 atm) at 60 °C gives the corresponding α-aminonitriles, which are versatile synthetic intermediates of various compounds such as amino acids and unsymmetrical 1,2-diamines, in excellent yields. This reaction is clean and should be an environmentally benign and useful process. Copyright © 2003 American Chemical Society.

引用

页码：15312 / 15313

页数：2

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