Exploring functional genomics for drug target and therapeutics discovery in Plasmodia

被引：13

作者：

Birkholtz, L. ^{[1
,2
]}

van Brummelen, A. C. ^{[1
]}

Clark, K. ^{[1
]}

Niemand, J. ^{[1
]}

Marechal, E. ^{[3
]}

Llinas, M. ^{[4
]}

Louw, A. I. ^{[1
,2
]}

机构：

[1] Univ Pretoria, Dept Biochem, ZA-0002 Pretoria, South Africa

[2] Univ Pretoria, African Ctr Gene Technol, ZA-0002 Pretoria, South Africa

[3] Univ Grenoble 1, Inst Rech & Technol & Sci le Vivant, CEA,UMR 5168 CNRS CEA INRA, Physiol Cellulaire Vegetale Lab, F-38054 Grenoble 09, France

[4] Princeton Univ, Lewis Sigler Inst Integrat Genom, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

ACTA TROPICA | 2008年 / 105卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

malaria; Plasmodium; functional genomics; transcriptome; proteome; interactome; drug target; therapeutics;

D O I：

10.1016/j.actatropica.2007.10.013

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学]; 100103 [病原生物学];

摘要：

Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：113 / 123

页数：11

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