Metal Ion Sensors Based on DNAzymes and Related DNA Molecules

被引：305

作者：

Zhang, Xiao-Bing ^{[1
]}

Kong, Rong-Mei ^{[1
]}

Lu, Yi ^{[2
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 4 | 2011年 / 4卷

关键词：

biosensors; fluorescence; colorimetry; electrochemistry; amplification; gold nanoparticles; IN-VITRO SELECTION; UNMODIFIED GOLD NANOPARTICLES; FREE COLORIMETRIC DETECTION; RNA-CLEAVING DEOXYRIBOZYME; SURFACE-PLASMON RESONANCE; CATALYTIC BEACON SENSOR; AQUEOUS-SOLUTION; MERCURY(II) IONS; POTASSIUM-ION; CONJUGATED POLYMERS;

D O I：

10.1146/annurev.anchem.111808.073617

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Metal ion sensors are an important yet challenging field in analytical chemistry. Despite much effort, only a limited number of metal ion sensors are available for practical use because sensor design is often a trial-and-error-dependent process. DNAzyme-based sensors, in contrast, can be developed through a systematic selection that is generalizable for a wide range of metal ions. Here, we summarize recent progress in the design of DNAzyme-based fluorescent, colorimetric, and electrochemical sensors for metal ions, such as Pb2+, Cu2+, Hg2+, and UO22+. In addition, we also describe metal ion sensors based on related DNA molecules, including T-T or C-C mismatches and G-quadruplexes.

引用

页码：105 / 128

页数：24

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