A convergent triflate displacement approach to (α-monofluoroalkyl)phosphonates

被引：29

作者：

Berkowitz, DB ^{[1
]}

Bose, M ^{[1
]}

Asher, NG ^{[1
]}

机构：

[1] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 13期

关键词：

D O I：

10.1021/ol015983z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of primary alkyl triflates or iodides with the potassium salt of diethyl (alpha -fluoro-alpha -phenylsulfonyl methyl)phosphonate yields (alpha -fluoro-alpha -phenylsulfonylalkyl)phosphonate These can be cleanly desulfonated, in a matter of minutes, with Na(HS) in MeOH/THF/NaH2PO4. This two-step procedure complements previously reported triflate displacement approaches to alpha -nonfluorinated and alpha,alpha -difluorinated phosphonates.

引用

页码：2009 / 2012

页数：4

共 46 条

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