Expression of vascular endothelial growth factor in human myocardial infarction

被引：67

作者：

Shinohara, K ^{[1
]}

Shinohara, T ^{[1
]}

Mochizuki, N ^{[1
]}

Mochizukik, Y ^{[1
]}

Sawa, H ^{[1
]}

Kohya, T ^{[1
]}

Fujita, M ^{[1
]}

Fujioka, Y ^{[1
]}

Kitabatake, A ^{[1
]}

Nagashima, K ^{[1
]}

机构：

[1] HOKKAIDO UNIV,SCH MED,DEPT CARDIOVASC MED,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

来源：

HEART AND VESSELS | 1996年 / 11卷 / 03期

关键词：

vascular endothelial growth factor (VEGF); acute myocardial infarction; human heart; in situ hybridization;

D O I：

10.1007/BF01745169

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the intensity of the VEGF signal was much higher in smooth muscle cells of arterioles adjacent to necrosis and in infiltrating macrophages than in myocytes around the site of the necrosis. This study suggests that levels of VEGF expression are high in smooth muscle cells and macrophages around infarcted areas after myocardial infarction and that VEGF may play a role in promoting collateral circulation and angiogenesis in human ischemic hearts.

引用

页码：113 / 122

页数：10

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