Active-site dynamics in RNA polymerases

被引：40

作者：

Landick, R ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

来源：

CELL | 2004年 / 116卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(04)00121-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New crystal structures of transcription complexes formed by bacteriophage T7 RNA polymerase reveal a nucleotide-addition cycle driven by active-site conformational changes similar to those observed in DNA polymerases, and suggest provocative hypotheses for the more complex multisubunit RNA polymerases of free-living organisms.

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收藏

页码：351 / 353

页数：3

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