New insights into riboswitch regulation mechanisms

被引：61

作者：

Bastet, Laurene ^{[1
]}

Dube, Audrey ^{[1
]}

Masse, Eric ^{[2
]}

Lafontaine, Daniel A. ^{[1
]}

机构：

[1] Univ Sherbrooke, Fac Sci, Dept Biol, Grp ARN RNA Grp, Sherbrooke, PQ J1K 2R1, Canada

[2] Univ Sherbrooke, Dept Biochim, Fac Med & Sci Sante, Grp ARN RNA Grp, Sherbrooke, PQ J1H 5N4, Canada

来源：

MOLECULAR MICROBIOLOGY | 2011年 / 80卷 / 05期

关键词：

THERMOSENSOR CONTROLS EXPRESSION; COLD-SHOCK PROTEIN; ESCHERICHIA-COLI; MESSENGER-RNA; LISTERIA-MONOCYTOGENES; BACILLUS-SUBTILIS; GENE-EXPRESSION; CANDIDATE; BACTERIA; BINDING;

D O I：

10.1111/j.1365-2958.2011.07654.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

P>Riboswitches are genetic elements located in non-coding regions of some messenger RNAs (mRNAs) that are present in all three domains of life. The binding of ligands to riboswitches induces conformational changes in the mRNA molecule, resulting in modulation of gene transcription, or RNA splicing, translation or stability. This mechanism of regulation is particularly widespread in bacteria and allows a direct response to various metabolic changes. A large number of riboswitches have been discovered in the last few years, suggesting the existence of a huge diversity of regulatory ligands and genetic mechanisms of regulation. This review focuses on recent discoveries in riboswitch regulatory mechanisms as well as current outstanding challenges.

引用

页码：1148 / 1154

页数：7

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