In vivo cancer imaging by poly(ethylene glycol)-b-poly(ε-caprolactone) micelles containing a near-infrared probe

被引:67
作者
Cho, Hyunah [1 ]
Indig, Guilherme L. [3 ]
Weichert, Jamey [4 ]
Shin, Ho-Chul [1 ]
Kwon, Glen S. [1 ,2 ]
机构
[1] Univ Wisconsin, Sch Pharm, Dept Pharmaceut Sci, Madison, WI 53705 USA
[2] Kyung Hee Univ, Coll Pharm, Seoul, South Korea
[3] Univ Wisconsin, Dept Chem & Biochem, Milwaukee, WI 53201 USA
[4] Univ Wisconsin, Sch Med & Publ Hlth, Dept Radiol, Madison, WI 53705 USA
关键词
Near infrared (NIR) fluorescence imaging; Poly(ethylene glycol)-b-poly(epsilon-caprolactone); Polymeric micelles; Self-quenching; FLUORESCENCE; COPOLYMER; NANOPARTICLES; NANOCARRIERS; PRODRUGS; THERAPY; RELEASE; SURGERY;
D O I
10.1016/j.nano.2011.06.009
中图分类号
TB3 [工程材料学];
学科分类号
082905 [生物质能源与材料];
摘要
Noninvasive near-infrared (NIR) fluorescence imaging is a promising technique for the intraoperative assessment of solid tumor removal. We incorporated a lipophilic NIR probe, 1,1'-dioctadecyltetramethyl indotricarbocyanine iodide (DiR), in poly(ethylene glycol)-b-poly(epsilon-caprolactone) (PEG-b-PCL) micelles, resulting in DiR solubilization in water, occupying nanoscopic PEG-b-PCL micelles. DiR in a self-quenched or nonquenched state showed different kinetics of release from PEG-b-PCL micelles in vitro; however, both obtained high tumor delineation (tumor-to-muscle ratio of 30-43 from collected organs). These results suggest that PEG-b-PCL micelles with DiR are a promising nanosized imaging agent that will provide a basis for enhanced surgical guidance via NIR visualization of tumors. From the Clinical Editor: In this paper, noninvasive near-infrared fluorescence imaging coupled with specific lipophilic probes is discussed as a promising technique for intraoperative assessment of solid tumor removal, leading to optimized outcomes for in toto removal of tumors. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:228 / 236
页数:9
相关论文
共 32 条
[1]
Near-Infrared Emitting Fluorophore-Doped Calcium Phosphate Nanoparticles for In Vivo Imaging of Human Breast Cancer [J].
Altinoglu, Erhan i. ;
Russin, Timothy J. ;
Kaiser, James M. ;
Barth, Brian M. ;
Eklund, Peter C. ;
Kester, Mark ;
Adair, James H. .
ACS NANO, 2008, 2 (10) :2075-2084
[2]
Behera GB, 2007, J SURFACE SCI TECHNO, V23, P2
[3]
Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(ε-caprolactone) micelle nanocarriers:: Pharmacokinetic disposition, tolerability, and cytotoxicity [J].
Forrest, M. Laird ;
Yanez, Jaime A. ;
Remsberg, Connie M. ;
Ohgami, Yusuke ;
Kwon, Glen S. ;
Davies, Neal M. .
PHARMACEUTICAL RESEARCH, 2008, 25 (01) :194-206
[4]
Lipophilic prodrugs of Hsp90 inhibitor geldanamycin for nanoencapsulation in poly(ethylene glycol)-b-poly(ε-caprolactone) micelles [J].
Forrest, M. Laird ;
Zhao, Anni ;
Won, Chee-Youb ;
Malick, A. Waseem ;
Kwon, Glen S. .
JOURNAL OF CONTROLLED RELEASE, 2006, 116 (02) :139-149
[5]
In vitro release of the mTOR inhibitor rapamycin from poly(ethylene glycol)-b-poly(ε-caprolactone) micelles [J].
Forrest, ML ;
Won, CY ;
Malick, AW ;
Kwon, GS .
JOURNAL OF CONTROLLED RELEASE, 2006, 110 (02) :370-377
[6]
In vivo near-infrared fluorescence imaging [J].
Frangioni, JV .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (05) :626-634
[7]
Optical imaging-guided cancer therapy with fluorescent nanoparticles [J].
Jiang, Shan ;
Gnanasammandhan, Muthu Kumara ;
Zhang, Yong .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2010, 7 (42) :3-18
[8]
Intraoperative near-infrared image-guided surgery for peritoneal carcinomatosis in a preclinical experimental model [J].
Keramidas, M. ;
Josserand, V. ;
Righini, C. A. ;
Wenk, C. ;
Faure, C. ;
Coll, J. L. .
BRITISH JOURNAL OF SURGERY, 2010, 97 (05) :737-743
[9]
Photophysics of cyanine dyes: Subnanosecond relaxation dynamics in monomers, dimers, and H- and J-aggregates in solution [J].
Khairutdinov, RF ;
Serpone, N .
JOURNAL OF PHYSICAL CHEMISTRY B, 1997, 101 (14) :2602-2610
[10]
Near-Infrared Phosphorescent Polymeric Nanomicelles: Efficient Optical Probes for Tumor Imaging and Detection [J].
Kumar, Rajiv ;
Ohulchanskyy, Tymish Y. ;
Roy, Indrajit ;
Gupta, Sandesh K. ;
Borek, Carsten ;
Thompson, Mark E. ;
Prasad, Paras N. .
ACS APPLIED MATERIALS & INTERFACES, 2009, 1 (07) :1474-1481