The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

被引：502

作者：

Lutter, Michael ^{[2
]}

Sakata, Ichiro ^{[1
,6
]}

Osborne-Lawrence, Sherri ^{[1
,6
]}

Rovinsky, Sherry A. ^{[1
,6
]}

Anderson, Jason G. ^{[1
,6
]}

Jung, Saendy ^{[2
]}

Birnbaum, Shari ^{[2
]}

Yanagisawa, Masashi ^{[3
,4
]}

Elmquist, Joel K. ^{[1
,2
,5
,6
]}

Nestler, Eric J. ^{[2
]}

Zigman, Jeffrey M. ^{[1
,6
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA

[4] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA

[5] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

[6] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Endocrinol & Metab, Dallas, TX 75390 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 07期

关键词：

D O I：

10.1038/nn.2139

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.

引用

页码：752 / 753

页数：2

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