Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

被引：1256

作者：

Meyer-Lindenberg, Andreas ^{[1
]}

Domes, Gregor ^{[2
]}

Kirsch, Peter ^{[1
]}

Heinrichs, Markus ^{[2
]}

机构：

[1] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, D-68159 Mannheim, Germany

[2] Univ Freiburg, Lab Biol & Personal Psychol, Dept Psychol, D-79104 Freiburg, Germany

来源：

NATURE REVIEWS NEUROSCIENCE | 2011年 / 12卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

RECEPTOR GENE OXTR; AUTISM SPECTRUM DISORDERS; MEDIAL PREFRONTAL CORTEX; ANXIETY-RELATED BEHAVIOR; STRESS-RELATED DISORDERS; HIGH-FUNCTIONING AUTISM; ADRENAL AXIS RESPONSES; ARGININE-VASOPRESSIN; INTRANASAL OXYTOCIN; NEURAL CIRCUITRY;

D O I：

10.1038/nrn3044

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are evolutionarily highly conserved mediators in the regulation of complex social cognition and behaviour. Recent studies have investigated the effects of OXT and AVP on human social interaction, the genetic mechanisms of inter-individual variation in social neuropeptide signalling and the actions of OXT and AVP in the human brain as revealed by neuroimaging. These data have advanced our understanding of the mechanisms by which these neuropeptides contribute to human social behaviour. OXT and AVP are emerging as targets for novel treatment approaches-particularly in synergistic combination with psychotherapy-for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia.

引用

页码：524 / 538

页数：15

共 187 条

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