Determination of anti-inflammatory drugs in water samples, by in situ derivatization, solid phase microextraction and gas chromatography-mass spectrometry

被引：61

作者：

Araujo, Lilia ^{[1
]}

Wild, Johana ^{[1
]}

Villa, Noreiva ^{[1
]}

Camargo, Nuris ^{[1
]}

Cubillan, Dalia ^{[1
]}

Prieto, Avismelsi ^{[1
]}

机构：

[1] Univ Zulia, Fac Engn, Lab Analyt Chem & Electrochim, Maracaibo 4011, Venezuela

来源：

TALANTA | 2008年 / 75卷 / 01期

关键词：

pharmaceutical residues; tap water and wastewater analysis; direct derivatization-SPME; GC-MS;

D O I：

10.1016/j.talanta.2007.10.035

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

A new analytical method for the determination of non-steroidal acidic anti-inflammatory drugs in water samples is described. These compounds Ire used as anti-inflammatory, antipyretic and analgesic drugs in human health care and in veterinary applications. Analytical procedure involves in situ derivatization of analytes to their methyl esters with dimethyl sulphate, headspace sampling using solid-phase microextraction (SPME), and gas chromatography-mass spectrometry (GC-MS). The effects of pH, ionic strength, extraction time, SPME fibre, extraction temperature as well as derivatization conditions were studied. Methyl esters were extracted with a fused-silica fibre coated with 100 mu m polydimethylsiloxane. Response was linearly dependent on concentration in the range 0.1-10.0 ng mL(-1). Detection limits were achieved at the level of 0.3-2.9 ng L-1. Derivatization-SPME/GC-MS analysis yielded good precision (R.S.D. between 7.9 and 17.2%). The method was validated by analysis of spiked matrix samples. (C) 2007 Elsevier B.V. All rights reserved.

引用

收藏

页码：111 / 115

页数：5

相关论文

共 28 条

[1]

Headspace solid phase microextraction. Dynamics and quantitative analysis before reaching a partition equilibrium [J].

Ai, J .

ANALYTICAL CHEMISTRY, 1997, 69 (16) :3260-3266

[2]

Occurrence and fate of pharmaceutically active compounds in the environment, a case study:: Hoje River in Sweden [J].

Bendz, D ;

Paxéus, NA ;

Ginn, TR ;

Loge, FJ .

JOURNAL OF HAZARDOUS MATERIALS, 2005, 122 (03) :195-204

[3]

Determination of chlorophenoxy acid herbicides in water by in situ esterification followed by in-vial liquid-liquid extraction combined with large-volume on-column injection and gas chromatography-mass spectrometry [J].

Catalina, MI ;

Dallüge, J ;

Vreuls, RJJ ;

Brinkman, UAT .

JOURNAL OF CHROMATOGRAPHY A, 2000, 877 (1-2) :153-166

[4]

Fate and analysis of pharmaceutical residues in the aquatic environment [J].

Debska, J ;

Kot-Wasik, A ;

Namiesnik, J .

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 2004, 34 (01) :51-67

[5]

Use of solid-phase microextraction followed by on-column silylation for determining chlorinated bisphenol A in human plasma by gas chromatography-mass spectrometry [J].

del Olmo, M ;

Zafra, A ;

Suárez, B ;

Gonzalez-Casado, A ;

Taoufiki, J ;

Vílchez, JL .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 817 (02) :167-172

[6]

Analysis of odorous trichlorobromophenols in water by in-sample derivatization/solid-phase microextraction GC/MS [J].

Diaz, Alfredo ;

Ventura, Francesc ;

Galceran, Maria Teresa .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2006, 386 (02) :293-298

[7]

Toxicological effects of disinfections using sodium hypochlorite on aquatic organisms and its contribution to AOX formation in hospital wastewater [J].

Emmanuel, E ;

Keck, G ;

Blanchard, JM ;

Vermande, P ;

Perrodin, Y .

ENVIRONMENT INTERNATIONAL, 2004, 30 (07) :891-900

[8]

Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry:: methods and preliminary results including toxicity studies with Vibrio fischeri [J].

Farré, ML ;

Ferrer, I ;

Ginebreda, A ;

Figueras, M ;

Olivella, L ;

Tirapu, L ;

Vilanova, M ;

Barceló, D .

JOURNAL OF CHROMATOGRAPHY A, 2001, 938 (1-2) :187-197

[9]

Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters [J].

Gros, Meritxell ;

Petrovic, Mira ;

Barcelo, Damia .

TALANTA, 2006, 70 (04) :678-690

[10]

Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data [J].

Heberer, T .

TOXICOLOGY LETTERS, 2002, 131 (1-2) :5-17