Aortic aneurysm diameter and risk of cardiovascular mortality

被引:80
作者
Brady, AR
Fowkes, FGR
Thompson, SG
Powell, JT
机构
[1] MRC, Clin Trials Unit, London NW1 2DA, England
[2] Univ Hosp Coventry, Coventry, W Midlands, England
[3] Univ Hosp Warwickshire, Coventry, W Midlands, England
[4] MRC, Biostat Unit, Cambridge CB2 2BW, England
[5] Univ Edinburgh, Dept Publ Hlth Sci, Edinburgh, Midlothian, Scotland
关键词
aneurysm; aorta; survival;
D O I
10.1161/hq0701.091999
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
After successful surgical repair of an abdominal aortic aneurysm, patients have for many years an increased risk of death from cardiovascular causes. We have tested the hypothesis that for patients with abdominal aortic aneurysms, the risk of nonaneurysm cardiovascular mortality before and after surgery increased with aneurysm diameter. Records of aneurysm repair or rupture and mortality were available from 2305 patients entered into the UK Small Aneurysm Trial and Study. Two hundred fifty-nine deaths occurred before aneurysm repair or rupture (mean follow-up 1.7 years), and 325 occurred after surgical repair (mean follow-up 3.6 years). The risk of nonaneurysm-related mortality and cardiovascular death before and after surgery increased with aneurysm diameter at baseline, even after adjustment for other known risk factors. The adjusted hazard ratios for cardiovascular mortality, per standard deviation (0.8-cm) increase in aneurysm diameter, were 1.34 (95% CI 1.01 to 1.79) and 1.31 (95% CI 1.06 to 1.63) in the periods before aneurysm repair or rupture and after aneurysm repair, respectively. The significant association between aortic diameter and cardiovascular mortality, excluding aneurysm-related deaths, suggests that aneurysm diameter is an independent marker of cardiovascular disease risk.
引用
收藏
页码:1203 / 1207
页数:5
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