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Dynamics of cAMP-dependent protein kinase

被引：327
作者：
Johnson, DA
Akamine, P
Radzio-Andzelm, E
Madhusudan
Taylor, SS
机构：
[1] Univ Calif San Diego, Howard Hughes Med Inst, Dept Chem & Biochem, La Jolla, CA 92093 USA
[2] Univ Calif Riverside, Div Biomed Sci, Riverside, CA 92521 USA
来源：
CHEMICAL REVIEWS | 2001年 / 101卷 / 08期
关键词：
D O I：
10.1021/cr000226k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The dynamics of cAMP-dependent protein kinase which provided a mechanism for cells to respond to external stimuli were studied. NMR spectroscopy were employed to monitor the dynamics of the protein and also provided high-resolution information of proteins in the solutions. The results showed that the correct assembly of the active kinase depended on the critical addition of a phosphate.
引用
收藏
页码：2243 / 2270
页数：28
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