Gold nanoparticles designed for combining dual modality imaging and radiotherapy

被引：25

作者：

Alric, Christophe ^{[1
]}

Serduc, Raphael ^{[2
]}

Mandon, Celine ^{[3
]}

Taleb, Jacqueline ^{[3
]}

Le Duc, Geraldine ^{[2
]}

Le Meur-Herland, Alice ^{[3
]}

Billotey, Claire ^{[3
]}

Perriat, Pascal ^{[4
]}

Roux, Stephane ^{[1
]}

Tillement, Olivier ^{[1
]}

机构：

[1] Univ Lyon 1, Lab Physicochim Mat Luminescents, UMR 5620, CNRS, F-69622 Villeurbanne, France

[2] European Synchrotron Radiat Facil, F-38000 Grenoble, France

[3] Univ Lyon 1, Lab CREATIS LRMN Animage, UMR 5220, CNRS INSERM INSA Lyon U630, F-69622 Villeurbanne, France

[4] Inst Natl Sci Appl, UMR 5510, CNRS, F-69621 Villeurbanne, France

来源：

GOLD BULLETIN | 2008年 / 41卷 / 02期

关键词：

D O I：

10.1007/BF03216586

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of gold nanoparticles; functionalized by gadolinium chelates constitutes an attractive way for combining imaging and therapy. The presence of gadolinium chelates allows monitoring their biodistribution after intravenous injection in small animals by magnetic resonance imaging (MRI) while the gold core strongly absorbs the X-ray photons. This feature is exploited for X-ray imaging but also for radiotherapy.

引用

页码：90 / 97

页数：8