Alarmins: awaiting a clinical response

被引：395

作者：

Chan, James K. ^{[1
]}

Roth, Johannes ^{[2
]}

Oppenheim, Joost J. ^{[3
]}

Tracey, Kevin J. ^{[4
]}

Vogl, Thomas ^{[2
]}

Feldmann, Marc ^{[1
]}

Horwood, Nicole ^{[1
]}

Nanchahal, Jagdeep ^{[1
]}

机构：

[1] Univ Oxford, Kennedy Inst Rheumatol, London W6 8LH, England

[2] Univ Munster, Inst Immunol, Munster, Germany

[3] NCI, Frederick, MD 21701 USA

[4] Feinstein Inst Med Res, New York, NY USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 08期

基金：

英国惠康基金;

关键词：

MOBILITY GROUP BOX-1; MYELOID-RELATED PROTEINS; EPITOPE-SPECIFIC IMMUNOTHERAPY; PROINFLAMMATORY S100 PROTEINS; JUVENILE IDIOPATHIC ARTHRITIS; ISCHEMIA-REPERFUSION INJURY; CALCIUM-BINDING PROTEINS; MESENCHYMAL STEM-CELLS; HEAT-SHOCK PROTEINS; DENDRITIC CELLS;

D O I：

10.1172/JCI62423

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread. Conversely, alarmins have also been found to play a major role in the orchestration of tissue homeostasis, including repair and remodeling in the heart, skin, and nervous system. Here, we provide an update and overview on alarmins, highlighting the areas that may benefit from this clinical translation.

引用

页码：2711 / 2719

页数：9

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