Therapeutic efficacy of theophylline in chronic lymphocytic leukemia

被引：23

作者：

Makower, D ^{[1
]}

Malik, U ^{[1
]}

Novik, Y ^{[1
]}

Wiernik, PH ^{[1
]}

机构：

[1] Montefiore Med Ctr, Albert Einstein Canc Ctr, Dept Oncol, Bronx, NY 10467 USA

来源：

MEDICAL ONCOLOGY | 1999年 / 16卷 / 01期

关键词：

chronic lymphocytic leukemia; theophylline; apoptosis; methylxanthine; cyclic adenosine monophosphate;

D O I：

10.1007/BF02787362

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Theophylline, a methylxanthine commonly used as a treatment for asthma, has been shown to induce apoptosis in chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo. We have treated three advanced CLL patients with theophylline, and seen responses in two. The clinical courses of the responders are presented, and the literature concerning theophylline as therapy for CLL is reviewed.

引用

页码：69 / 71

页数：3

共 11 条

[1]

Binet JL, 1995, B ACAD NAT MED PARIS, V179, P1379

[2]

Binet JL, 1995, LEUKEMIA, V9, P2159

[3] INDUCTION OF APOPTOSIS IN FIBROBLASTS BY C-MYC PROTEIN [J].

EVAN, GI ;

WYLLIE, AH ;

GILBERT, CS ;

LITTLEWOOD, TD ;

LAND, H ;

BROOKS, M ;

WATERS, CM ;

PENN, LZ ;

HANCOCK, DC .

CELL, 1992, 69 (01) :119-128

[4]

Hardman J.G., 1996, Goodman and Gilman's The Pharmacological Basis of Therapeutics, V9th

[5]

KOMLOS L, 1986, ASIAN PAC J ALLERGY, V4, P89

[6]

LALLI E, 1994, J BIOL CHEM, V269, P17359

[7] The role of theophylline in the management of chronic asthma in adults [J].

McDonald, CJ ;

Holgate, ST .

CLINICAL AND EXPERIMENTAL ALLERGY, 1996, 26 :42-46

[8] Theophylline synergizes with chlorambucil in inducing apoptosis of B-chronic lymphocytic leukemia cells [J].

Mentz, F ;

Mossalayi, MD ;

Ouaaz, F ;

Baudet, S ;

Issaly, F ;

Ktorza, S ;

Semichon, M ;

Binet, JL ;

MerleBeral, H .

BLOOD, 1996, 88 (06) :2172-2182

[9] THEOPHYLLINE, A NEW INDUCER OF APOPTOSIS IN B-CLL - ROLE OF CYCLIC-NUCLEOTIDES [J].

MENTZ, F ;

MERLEBERAL, H ;

OUAAZ, F ;

BINET, JL .

BRITISH JOURNAL OF HAEMATOLOGY, 1995, 90 (04) :957-959

[10]

MIYASHITA T, 1993, BLOOD, V81, P151

← 1 2 →