The endoproteolytic processing of αvβ5 integrin is involved in cytoskeleton remodelling and cell migration

被引：6

作者：

Berthet, V ^{[1
]}

Rigot, V ^{[1
]}

Nejjari, M ^{[1
]}

Marvaldi, J ^{[1
]}

Luis, J ^{[1
]}

机构：

[1] Fac Pharm Marseille, CNRS UMR6032, F-13385 Marseille 5, France

来源：

FEBS LETTERS | 2004年 / 557卷 / 1-3期

基金：

澳大利亚研究理事会;

关键词：

proprotein convertase; endoproteolytic cleavage; alpha v beta 5 integrin; alpha; 1-PDX; actin cytoskeleton; colon carcinoma;

D O I：

10.1016/S0014-5793(03)01467-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously showed that the post-translational cleavage of alphav subunit is essential for integrin-dependent signalling and cell adhesion. Here, we report that blocking av subunit cleavage by expression of alpha1-PDX, a convertase inhibitor, modified the capacity of cells to change shape, via a remodelling of the actin cytoskeleton upon cell attachment. These changes are associated with cell scattering and with a dramatic increase in cell migration to vitronectin. The alphav subunit cleavage is thus essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：159 / 163

页数：5

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