A role of inhibitor of apoptosis (IAP) proteins in increased lymphocyte apoptosis in aged humans

被引：10

作者：

Gupta, S ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Med, Div Basic & Med Sci 1, Irvine, CA 92697 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2004年 / 125卷 / 02期

关键词：

apoptosis; lymphocytes; T cell; IAPs; aging; caspases;

D O I：

10.1016/j.mad.2003.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lymphocytes from aged humans show increased death-receptor-mediated apoptosis, which is associated with an increased and early activation of caspases. Inhibitor of apoptosis (IAP) proteins inhibit apoptosis by inhibiting activation and activity of caspases. Therefore, we examine the expression of two of the IAPs, the cIAP-2 and XIAP in lymphocytes from young and aged subjects by Western blotting. Lymphocytes from aged expressed significantly less cIAP2 whereas no difference was observed in XIAP expression between young and aged subjects. These data may suggest that decreased cIAP2 may play a role in increased apoptosis in aged humans. Possible mechanisms for the regulation of IAPs in aging are discussed. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：99 / 101

页数：3

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