Facile reduction of tertiary lactams to cyclic amines with 9-borabicyclo[3.3.1]nonane (9-BBN)

被引：33

作者：

Collins, CJ ^{[1
]}

Lanz, M ^{[1
]}

Singaram, B ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(99)00556-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various 5- and 6-membered tertiary lactams were reduced to the corresponding cyclic tertiary amines using 2.2 to 2.5 equivalents of 9-borabicyclo[3.3.1]nonane (9-BBN). This method is highly chemoselective and it is easy to reduce a lactam in the presence of an ester. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3673 / 3676

页数：4

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