Reduction of amides to amines via catalytic hydrosilylation by a rhodium complex

被引：157

作者：

Kuwano, R ^{[1
]}

Takahashi, M ^{[1
]}

Ito, Y ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Div Synthet Chem & Biol Chem, Sakyo Ku, Kyoto 60601, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(97)10804-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reduction of a wide range of tertiary amides with 2 molar equivalents of diphenylsilane was promoted by 0.1 mol% of RhH(CO)(PPh3)3 at room temperature, affording the corresponding tertiary amines in high yields. The synthetic utility is demonstrated by chemoselective reductions of amides having functional groups such as ester and epoxy groups which are not tolerated by the conventional reductions with LiAlH4 and BH3. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1017 / 1020

页数：4

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