p53 Activation by small molecules: Application in oncology

被引:152
作者
Vassilev, LT [1 ]
机构
[1] Hoffmann La Roche Inc, Roche Res Ctr, Discovery Oncol, Nutley, NJ 07110 USA
关键词
D O I
10.1021/jm058174k
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:4491 / 4499
页数:9
相关论文
共 65 条
[1]   Post-translational modifications and activation of p53 by genotoxic stresses [J].
Appella, E ;
Anderson, CW .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (10) :2764-2772
[2]   Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream [J].
Arkin, MR ;
Wells, JA .
NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (04) :301-317
[3]  
Ashcroft M, 1999, MOL CELL BIOL, V19, P1751
[4]   Cyclotherapy Protection of Normal Cells and Unshielding of Cancer Cells [J].
Blagosklonny, Mikhail V. ;
Darzynkiewicz, Zbigniew .
CELL CYCLE, 2002, 1 (06) :375-382
[5]   Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs [J].
Blagosklonny, MV ;
Robey, R ;
Bates, S ;
Fojo, T .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (04) :533-539
[6]  
Blagosklonny MV, 2001, CANCER RES, V61, P4301
[7]   Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo [J].
Bottger, A ;
Bottger, V ;
Sparks, A ;
Liu, WL ;
Howard, SF ;
Lane, DP .
CURRENT BIOLOGY, 1997, 7 (11) :860-869
[8]   Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation [J].
Brooks, CL ;
Gu, W .
CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (02) :164-171
[9]   Requirement for p53 and p21 to sustain G2 arrest after DNA damage [J].
Bunz, F ;
Dutriaux, A ;
Lengauer, C ;
Waldman, T ;
Zhou, S ;
Brown, JP ;
Sedivy, JM ;
Kinzler, KW ;
Vogelstein, B .
SCIENCE, 1998, 282 (5393) :1497-1501
[10]   Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors [J].
Carvajal, D ;
Tovar, C ;
Yang, H ;
Vu, BT ;
Heimbrook, DC ;
Vassilev, LT .
CANCER RESEARCH, 2005, 65 (05) :1918-1924