Repetitive transcranial magnetic stimulation has a beneficial effect on bradykinesia in Parkinson's disease

被引：184

作者：

Siebner, HR ^{[1
]}

Mentschel, C ^{[1
]}

Auer, C ^{[1
]}

Conrad, B ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Neurol, D-81675 Munich, Germany

来源：

NEUROREPORT | 1999年 / 10卷 / 03期

关键词：

bradykinesia; motor cortex; Parkinson's disease; repetitive transcranial magnetic stimulation (rTMS);

D O I：

10.1097/00001756-199902250-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

THE effect of focal 5 Hz repetitive transcranial magnetic stimulation (rTMS) of the motor hand area (M1) on bradykinesia was studied in 12 unmedicated patients with Parkinson's disease (PD). On 2 separate days, a real-rTMS was applied to M1 contralaterally to the more severely affected limb or a frontal sham-rTMS was applied 3 cm anteriorly to Fz in a random order. Stimulus intensity was 10% below resting motor threshold. Before and 20 min after rTMS, patients performed 15 consecutive pointing movements with the index finger contralaterally to the stimulated M1. Compared with sham-rTMS, real-rTMS over the contralateral M1 caused a significant decrease in total movement time without affecting end-point accuracy. Our data provide evidence that 5 Hz rTMS over M1 can improve bradykinesia in PD patients beyond the time of magnetic stimulation. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：589 / 594

页数：6

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