One-pot, new stereoselective synthesis of endo-tropanamine

被引：35

作者：

Allegretti, M ^{[1
]}

Berdini, V ^{[1
]}

Cesta, MC ^{[1
]}

Curti, R ^{[1
]}

Nicolini, L ^{[1
]}

Topai, A ^{[1
]}

机构：

[1] Dompe SPA, Dept Chem, Res & Dev Ctr, I-67100 Laquila, Italy

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 25期

关键词：

reductive amination; tropanamine; stereoselectivity;

D O I：

10.1016/S0040-4039(01)00663-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalysed reduction of ketones to primary amines by reaction with ammonium formate in aqueous methanol is described. The proposed method provides a one-pot synthesis of 3-endo-tropanamine in high yields and stereoselectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4257 / 4259

页数：3

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