Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB)

被引：107

作者：

Mäding, P ^{[1
]}

Füchtner, F ^{[1
]}

Wüst, F ^{[1
]}

机构：

[1] Rossendorf Inc, Forschungszentrum Rossendorf EV, Inst Bioanorgan & Radiopharmazeut, D-01314 Dresden, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 2005年 / 63卷 / 03期

关键词：

F-18-labelling; positron emission tomography (PET); F-18]SFB; automated module synthesis;

D O I：

10.1016/j.apradiso.2005.03.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

The three-step radiosynthesis of N-succinimidyl 4-[F-18]fluorobenzoate ([F-18]SFB) was adapted to a remotely controlled synthesis module. After optimization of the reaction conditions, the final [F-18]SFB was obtained in decay-corrected radiochemical yields of 34-38% (related to [F-18]fluoride; n = 12) within a synthesis time of 68 min. The radiochemical purity was in the range of 93-96%. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：329 / 332

页数：4

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