A compound isolated from Schisandra chinensis induces apoptosis

被引：40

作者：

Hwang, Doseok ^{[2
]}

Shin, Soon Young ^{[1
]}

Lee, Younggiu ^{[2
]}

Hyun, Jiye ^{[2
]}

Yong, Yeonjoong ^{[2
]}

Park, Jun Cheol ^{[3
]}

Lee, Young Han ^{[1
]}

Lim, Yoongho ^{[2
]}

机构：

[1] Konkuk Univ, SMART Inst Adv Biomed Sci, Dept Biomed Sci & Technol, Seoul 143701, South Korea

[2] Konkuk Univ, BMIC, Div Biosci & Biotechnol, Seoul 143701, South Korea

[3] Rural Dev Adm, Natl Inst Anim Sci, Suwon 441706, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 20期

关键词：

Apoptosis; Schisandra chinensis; Caspase-7; Clonogenic assay; HIGHLY OXYGENATED NORTRITERPENOIDS; GOMISIN-A; IN-VITRO; CELLS; BAILL; CONSTITUENTS; LIGNANS;

D O I：

10.1016/j.bmcl.2011.08.065

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Schizandra chinensis has been known to have five predominant tastes: salty, sweet, sour, astringent, and bitter. It has also been shown to have various effects on the cardiovascular system, gastrointestinal system, anti-inflammatory, central nervous system, endocrine system, and stress protect. However, its anticancer activity on colon carcinoma HCT-116 cells has not been yet been examined. Thus, in this study, we attempted to isolate a compound from Schisandra chinensis that induced apoptosis in HCT-116 cells. An active compound was found and identified to be Gomisin A. It displayed apoptotic activity through caspase-7 cleavage in colon carcinoma HCT-116 cells. In addition, we further assessed the effects of this compound using long-term survival clonogenic assay with HCT116 cells. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6054 / 6057

页数：4

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