New pentacyclic triterpenes from Gypsophila oldhamiana and their biological evaluation as glycogen phosphorylase inhibitors

被引：28

作者：

Luo, Jian-Guang ^{[1
]}

Liu, Jun ^{[2
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Nanjing 210038, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 05期

关键词：

D O I：

10.1002/cbdv.200890071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The three new pentacyclic triterpenes 1-3 were isolated and elucidated from the roots of Gypsophila oldhamiana, together with seven known triterpenes (4-10). These triterpenes were evaluated for their glycogen phosphorylase inhibitory activity and preliminary structure-activity trends are suggested.

引用

页码：751 / 757

页数：7

共 21 条

[1]

Two new sulfated saponins from the roots of Gypsophila bermejoi [J].

Acebes, B ;

Bernabé, M ;

Díaz-Lanza, AM ;

Bartolomé, C .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (12) :1557-1559

[2]

TRITERPENOIDS .15. THE CONSTITUTION OF ICTEROGENIN, A PHYSIOLOGICALLY ACTIVE TRITERPENOID [J].

BARTON, DHR ;

DEMAYO, P .

JOURNAL OF THE CHEMICAL SOCIETY, 1954, (MAR) :887-900

[3]

Oleanane triterpenes from Junellia tridens [J].

Caldwell, CG ;

Franzblau, SG ;

Suarez, E ;

Timmermann, BN .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (12) :1611-1614

[4]

Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase [J].

Chen, J ;

Liu, J ;

Zhang, LY ;

Wu, GZ ;

Hua, WY ;

Wu, XM ;

Sun, HB .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (11) :2915-2919

[5]

Triterpenoid saponins from Spergularia ramosa [J].

De Tommasi, N ;

Piacente, S ;

Gacs-Baitz, E ;

De Simone, F ;

Pizza, C ;

Aquino, R .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (03) :323-327

[6]

Gaidi G, 2005, PHARMAZIE, V60, P635

[7]

*JIANS COLL NEW ME, 1977, DICT TRADITIONAL CHI, P2170

[8]

Triterpenoid saponins from Gypsophila oldhamiana [J].

Liu, ZM ;

Li, D ;

Owen, NL ;

Grant, DM ;

Cates, RG ;

Jia, ZJ .

JOURNAL OF NATURAL PRODUCTS, 1995, 58 (10) :1632-1635

[9]

LU DQ, 1994, ZHIWUYANGJIU, V14, P229

[10]

Gypsophin:: A novel α-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana [J].

Luo, Jian-Guang ;

Wang, Xiao-Bing ;

Ma, Li ;

Kong, Ling-Yi .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (16) :4460-4463

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