Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

被引：98

作者：

Sonnen, Joshua A. ^{[2
,3
,4
]}

Breitner, John C. ^{[2
,3
,4
]}

Lovell, Mark A. ^{[2
,3
,4
]}

Markesbery, William R. ^{[2
,3
,4
]}

Quinn, Joseph F. ^{[2
,3
,4
]}

Montine, Thomas J. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Washington, Dept Pathol, Harborview Med Ctr, Seattle, WA 98104 USA

[2] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98104 USA

[3] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[4] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2008年 / 45卷 / 03期

关键词：

Alzheimer's disease; mild cognitive impairement; oxidative damage; anti-oxidants;

D O I：

10.1016/j.freeradbiomed.2008.04.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances in our understanding of the etiologies and pathogenesis of Alzheimer's disease (AD) highlight a role for free radical-mediated injury to brain regions from early stages of this illness. Here we will review the evidence from transgenic mouse models of AD, autopsy samples, and human biofluids obtained during life paying particular attention to the stage of disease. In addition, we Will review the epidemiologic literature that addresses the potential of anti-oxidants to prevent incident dementia from AD, and the clinical trial literature that addresses anti-oxidant preventative or therapeutic strategies for different stage of AD. Future efforts in preclinical models and ultimately clinical trials are needed to define optimally effective agents and combinations, doses, and timing to suppress safely this facet of AD. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：219 / 230

页数：12

共 180 条

[51] Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study [J].