Neurogenic Hypertension and Elevated Vertebrobasilar Arterial Resistance: Is There a Causative Link?

被引：46

作者：

Cates, Matthew J. ^{[2
,3
]}

Dickinson, C. John ^{[4
]}

Hart, Emma C. J. ^{[1
]}

Paton, Julian F. R. ^{[1
]}

机构：

[1] Univ Bristol, Sch Physiol & Pharmacol, Bristol Heart Inst, Bristol BS8 1TD, Avon, England

[2] Torbay Hosp, Lawes Bridge TQ2 7AA, Torquay, England

[3] Univ Bristol, Dept Physiol & Pharmacol, Bristol Heart Inst, Sch Med Sci, Bristol BS8 1TD, Avon, England

[4] Barts & London Sch Med & Dent Charterhouse Sq, Wolfson Inst Preventat Med, London EC1M 6BQ, England

来源：

CURRENT HYPERTENSION REPORTS | 2012年 / 14卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Hypertension; Secondary hypertension; Neurogenic; Essential; Vertebral; Basilar; Vertebrobasilar; Elevated; Brainstem; Resistance; Arterial; Sympathetic; SNA; Cushing's; LONG-TERM CONTROL; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CEREBRAL-BLOOD-FLOW; ANGIOTENSIN-II; BRAIN-STEM; SYMPATHETIC ACTIVITY; NORMOTENSIVE SUBJECTS; MEDULLA-OBLONGATA; PRESSOR-RESPONSE; FAMILY-HISTORY;

D O I：

10.1007/s11906-012-0267-6

中图分类号：

R6 [外科学];

学科分类号：

100210 [外科学];

摘要：

There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.

引用

页码：261 / 269

页数：9

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