A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing

被引：39

作者：

Ravula, Surendra K. ^{[1
]}

Branch, Darren W. ^{[1
]}

James, Conrad D. ^{[1
]}

Townsend, Rosemary J. ^{[2
]}

Hill, Martyn ^{[2
]}

Kaduchak, Gregory ^{[3
]}

Ward, Mike ^{[3
]}

Brener, Igal ^{[1
]}

机构：

[1] Sandia Natl Labs, Albuquerque, NM 87123 USA

[2] Univ Southampton, Southampton SO17 1BJ, Hants, England

[3] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2008年 / 130卷 / 02期

关键词：

acoustics; dielectrophoresis; microfluidics; particle focusing;

D O I：

10.1016/j.snb.2007.10.024

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

Microfabricated systems have recently become useful for routing particles to precise locations in microfluidic channels. In this paper we discuss the modeling, fabrication and characterization of such a platform that combines acoustic forces and ac dielectrophoresis (DEP). This system integrates a bulk lead zirconate titanate (PZT) slab with substrate patterned microelectrodes for DEP manipulation of particles. Moreover, a one-dimensional transmission line model is presented to understand the coupling of the acoustic and dielectrophoretic transducers with the microdevice. While the acoustic model does not predict the lateral coupling in the system, it does provide some insight into axial (thickness-mode) frequencies of operation. Experiments are also conducted in which particles were routed into a large (0.75 mm wide) microchannel and preconcentrated and focused into coarse bundles by coupling an acoustic wave into the channel. Subsequently, particles are further focused into single file particle streams using interdigitated DEP electrodes. This system can be used for high throughput assays for which it is necessary to isolate and investigate small bundles of particles and single particles. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：645 / 652

页数：8

共 24 条

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